Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 972)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0299383	0.1192530	0.8042169
Weighted median	23	-0.0997295	0.0650371	0.1251712
Inverse variance weighted	23	-0.0701266	0.0464314	0.1309600
Simple mode	23	-0.2129395	0.1215573	0.0937447
Weighted mode	23	-0.1282012	0.0811453	0.1284022

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.97285	21	0.0925350
Inverse variance weighted	31.15897	22	0.0929082

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.006145	0.0067408	0.3723184

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010421	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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