Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 971)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0037391	0.1334733	0.9779155
Weighted median	23	0.0026022	0.0583679	0.9644400
Inverse variance weighted	23	0.0451007	0.0511606	0.3780194
Simple mode	23	-0.0165874	0.1112197	0.8828009
Weighted mode	23	-0.0165874	0.0610750	0.7884688

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.54631	21	0.0145586
Inverse variance weighted	37.82887	22	0.0191484

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029992	0.0075445	0.6949826

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011867	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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