Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 970)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0684325	0.0998209	0.5004938
Weighted median	23	0.0451792	0.0545613	0.4076448
Inverse variance weighted	23	0.0127750	0.0390156	0.7433403
Simple mode	23	0.0638431	0.0827859	0.4488029
Weighted mode	23	0.0472717	0.0651770	0.4759234

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.93239	21	0.5894773
Inverse variance weighted	19.29934	22	0.6267787

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034179	0.0056424	0.5511654

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000588	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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