Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 97)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0904756	0.0998207	0.3750168
Weighted median	23	0.0211152	0.0575084	0.7134947
Inverse variance weighted	23	0.0206181	0.0390156	0.5971818
Simple mode	23	0.0138709	0.0906829	0.8798239
Weighted mode	23	0.0138709	0.0695827	0.8438247

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.40407	21	0.5592365
Inverse variance weighted	19.98215	22	0.5841566

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0042899	0.0056423	0.4555202

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006139	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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