Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 969)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0617137	0.1037659	0.5583717
Weighted median	23	0.0008116	0.0587105	0.9889707
Inverse variance weighted	23	-0.0018055	0.0399949	0.9639922
Simple mode	23	-0.0121932	0.0971508	0.9012614
Weighted mode	23	-0.0213547	0.0812803	0.7952042

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.69293	21	0.3605669
Inverse variance weighted	23.11807	22	0.3950886

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.003679	0.0058654	0.5372652

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007006	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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