Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 968)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0660898	0.0998203	0.5151158
Weighted median	23	-0.0433666	0.0573616	0.4496364
Inverse variance weighted	23	-0.0134176	0.0390157	0.7309196
Simple mode	23	-0.0492588	0.0964515	0.6146404
Weighted mode	23	-0.0552954	0.0793923	0.4934204

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.72559	21	0.9179311
Inverse variance weighted	13.47441	22	0.9190803

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0048826	0.0056423	0.3966291

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004119	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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