Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 967)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1661067	0.0998201	0.1109525
Weighted median	23	0.0307131	0.0530532	0.5626481
Inverse variance weighted	23	-0.0374872	0.0390156	0.3366403
Simple mode	23	-0.1818553	0.0978309	0.0764746
Weighted mode	23	0.0365728	0.0717362	0.6152516

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.83307	21	0.8312337
Inverse variance weighted	19.74319	22	0.5990999

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0125026	0.0056423	0.0378801

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006263	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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