Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 966)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0761873	0.0998201	0.4538065
Weighted median	23	0.0604978	0.0554008	0.2748325
Inverse variance weighted	23	0.1105770	0.0390154	0.0045942
Simple mode	23	0.1749152	0.1019039	0.1001247
Weighted mode	23	0.0696570	0.0605905	0.2626387

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.49317	21	0.6808130
Inverse variance weighted	21.62507	22	0.4824487

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0114691	0.0056423	0.0549186

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008987	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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