Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 965)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0169227	0.1054767	0.8740676
Weighted median	23	0.0266526	0.0537448	0.6199580
Inverse variance weighted	23	0.0346979	0.0403106	0.3893681
Simple mode	23	0.0538587	0.0882036	0.5477101
Weighted mode	23	0.0396104	0.0594737	0.5123251

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.44731	21	0.3206004
Inverse variance weighted	23.48473	22	0.3748056

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010916	0.005962	0.8564859

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007356	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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