Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 964)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1412005	0.1098721	0.2127390
Weighted median	23	0.0177368	0.0574154	0.7573815
Inverse variance weighted	23	0.0425898	0.0428964	0.3207813
Simple mode	23	0.1489559	0.1027980	0.1614383
Weighted mode	23	0.0275860	0.0724766	0.7071358

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.44276	21	0.2284974
Inverse variance weighted	26.59466	22	0.2270273

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0060557	0.0062105	0.3406248

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000842	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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