Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 963)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0179271	0.1123443	0.8747426
Weighted median	23	0.0161480	0.0570102	0.7769873
Inverse variance weighted	23	-0.0097558	0.0429074	0.8201369
Simple mode	23	-0.0021959	0.1114550	0.9844589
Weighted mode	23	-0.0253867	0.0915016	0.7840286

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.60085	21	0.1844587
Inverse variance weighted	26.60876	22	0.2264642

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0005018	0.0063503	0.9377649

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008082	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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