Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 962)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1848327	0.1115267	0.1123254
Weighted median	23	-0.0319015	0.0561692	0.5700666
Inverse variance weighted	23	0.0091231	0.0460666	0.8430135
Simple mode	23	-0.0349013	0.1074368	0.7483605
Weighted mode	23	-0.0680503	0.0607597	0.2747968

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.21442	21	0.1983909
Inverse variance weighted	30.67064	22	0.1030546

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0119108	0.006304	0.0727258

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000931	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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