Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 961)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0584107	0.1340694	0.6675180
Weighted median	23	0.0611909	0.0608408	0.3145335
Inverse variance weighted	23	0.0732538	0.0512151	0.1526262
Simple mode	23	0.0565625	0.0968361	0.5650914
Weighted mode	23	0.0488282	0.0634969	0.4500797

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.88353	21	0.0132995
Inverse variance weighted	37.90963	22	0.0187542

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009115	0.0075782	0.9054047

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012555	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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