Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 960)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0691790	0.1158893	0.5569289
Weighted median	23	-0.0198191	0.0552752	0.7199299
Inverse variance weighted	23	0.0063668	0.0446186	0.8865315
Simple mode	23	-0.0868447	0.0961683	0.3762814
Weighted mode	23	-0.0273114	0.0566654	0.6345821

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.30539	21	0.1317008
Inverse variance weighted	28.77275	22	0.1514641

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0038573	0.0065506	0.5622475

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008727	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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