Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 96)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0061754	0.0998208	0.9512559
Weighted median	23	0.0349353	0.0576869	0.5447793
Inverse variance weighted	23	0.0224916	0.0390158	0.5642951
Simple mode	23	-0.0115282	0.0932735	0.9027577
Weighted mode	23	0.0140662	0.0640375	0.8281643

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.49666	21	0.7411293
Inverse variance weighted	16.52819	22	0.7888357

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001002	0.0056423	0.8607534

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005109	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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