Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 959)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3073287	0.0998178	0.0056930
Weighted median	23	-0.1687935	0.0550697	0.0021760
Inverse variance weighted	23	-0.1051134	0.0414678	0.0112505
Simple mode	23	-0.1706333	0.0811712	0.0472115
Weighted mode	23	-0.1706333	0.0542672	0.0047100

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.00932	21	0.5206709
Inverse variance weighted	24.85340	22	0.3041367

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0124182	0.0056422	0.0390655

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009731	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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