Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 958)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0538069	0.1038184	0.6096820
Weighted median	23	-0.0990889	0.0581243	0.0882362
Inverse variance weighted	23	-0.0558379	0.0396458	0.1590065
Simple mode	23	-0.0855443	0.0959983	0.3825167
Weighted mode	23	-0.1114726	0.0693321	0.1221359

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.71601	21	0.3593051
Inverse variance weighted	22.71650	22	0.4178831

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001247	0.0058683	0.9832434

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007504	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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