Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 957)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0214449	0.1074165	0.8436805
Weighted median	23	0.0122325	0.0560025	0.8270954
Inverse variance weighted	23	0.0332606	0.0410333	0.4176100
Simple mode	23	0.1187429	0.0943539	0.2214090
Weighted mode	23	0.0113130	0.0622600	0.8574771

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.31775	21	0.2779188
Inverse variance weighted	24.33429	22	0.3299539

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007256	0.0060717	0.9060113

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007594	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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