Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 956)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0553600	0.1045576	0.6020332
Weighted median	23	-0.0089719	0.0544643	0.8691563
Inverse variance weighted	23	0.0565233	0.0411921	0.1700049
Simple mode	23	-0.0055760	0.1093444	0.9597897
Weighted mode	23	-0.0152278	0.0610200	0.8052475

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.04033	21	0.3418316
Inverse variance weighted	24.52315	22	0.3204167

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0068707	0.0059101	0.2580573

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008067	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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