Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 955)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0404258	0.1132347	0.7246474
Weighted median	23	0.0339898	0.0574705	0.5542317
Inverse variance weighted	23	0.0296647	0.0432521	0.4928033
Simple mode	23	0.1111515	0.1059753	0.3056363
Weighted mode	23	0.0635480	0.0660200	0.3462315

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.02356	21	0.1700747
Inverse variance weighted	27.03728	22	0.2098140

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006608	0.0064006	0.9187467

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008368	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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