Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 954)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0210685	0.1176934	0.8596441
Weighted median	23	-0.0109463	0.0548332	0.8417712
Inverse variance weighted	23	-0.0070459	0.0449616	0.8754732
Simple mode	23	0.0121304	0.0838971	0.8863534
Weighted mode	23	-0.0274121	0.0593070	0.6484712

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.19310	21	0.1094423
Inverse variance weighted	29.21639	22	0.1387859

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008611	0.0066526	0.8982396

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008863	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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