Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 953)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0410607	0.1152012	0.7250779
Weighted median	23	0.0596616	0.0567235	0.2928930
Inverse variance weighted	23	0.0653331	0.0440468	0.1380037
Simple mode	23	-0.0041813	0.0944555	0.9650906
Weighted mode	23	0.0518826	0.0625598	0.4158275

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.97029	21	0.1409959
Inverse variance weighted	28.04008	22	0.1743567

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014906	0.0065117	0.8211572

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009346	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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