Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 952)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0862153	0.1290983	0.5115176
Weighted median	23	-0.0295256	0.0564655	0.6010468
Inverse variance weighted	23	-0.0365853	0.0495030	0.4598752
Simple mode	23	0.1072139	0.1022677	0.3058518
Weighted mode	23	-0.0237338	0.0632752	0.7111869

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.12533	21	0.0273537
Inverse variance weighted	35.41710	22	0.0350270

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030478	0.0072972	0.6804354

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010998	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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