Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 951)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0286677	0.1037412	0.7849891
Weighted median	23	0.0478265	0.0556624	0.3902163
Inverse variance weighted	23	0.0628551	0.0397364	0.1136948
Simple mode	23	0.2243057	0.1048162	0.0436969
Weighted mode	23	0.0241468	0.0651245	0.7143480

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.68202	21	0.3611641
Inverse variance weighted	22.82046	22	0.4119261

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020994	0.0058639	0.7238986

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007702	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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