Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 950)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0468298	0.1187032	0.6971816
Weighted median	23	0.0178585	0.0570420	0.7542230
Inverse variance weighted	23	-0.0079940	0.0456003	0.8608396
Simple mode	23	-0.0685579	0.1017781	0.5075801
Weighted mode	23	0.0666743	0.0661184	0.3242214

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.69665	21	0.0982554
Inverse variance weighted	30.05269	22	0.1171893

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0033667	0.0067097	0.6210488

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009119	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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