Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 95)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1949732	0.0998201	0.0642438
Weighted median	23	-0.0189904	0.0567605	0.7379491
Inverse variance weighted	23	0.0177806	0.0390155	0.6485828
Simple mode	23	-0.1169838	0.1005145	0.2569522
Weighted mode	23	-0.0223410	0.0672809	0.7429901

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.98936	21	0.9089961
Inverse variance weighted	16.70859	22	0.7792331

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0108814	0.0056423	0.0674173

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005126	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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