Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 949)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0130021	0.0998209	0.8976047
Weighted median	23	-0.0078654	0.0549389	0.8861588
Inverse variance weighted	23	0.0004167	0.0390157	0.9914795
Simple mode	23	-0.0126956	0.0904670	0.8896730
Weighted mode	23	-0.0098976	0.0661211	0.8823733

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.41826	21	0.5583280
Inverse variance weighted	19.43703	22	0.6182095

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007729	0.0056424	0.8923539

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000589	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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