Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 948)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0074919	0.1073160	0.9450045
Weighted median	23	-0.0450523	0.0558899	0.4201906
Inverse variance weighted	23	-0.0302115	0.0411230	0.4625455
Simple mode	23	-0.0378776	0.0816871	0.6474244
Weighted mode	23	-0.0554676	0.0619734	0.3804627

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.27251	21	0.2800427
Inverse variance weighted	24.44091	22	0.3245497

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0023154	0.006066	0.7065235

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007588	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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