Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 947)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1337033	0.1056586	0.2195792
Weighted median	23	0.0323630	0.0585414	0.5803850
Inverse variance weighted	23	0.0631087	0.0408512	0.1223848
Simple mode	23	-0.0600307	0.1072944	0.5814760
Weighted mode	23	0.0357066	0.0715042	0.6224804

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.52901	21	0.3164338
Inverse variance weighted	24.11937	22	0.3410033

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043352	0.0059723	0.4759237

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008101	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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