Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 946)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0093767	0.1229887	0.9399494
Weighted median	23	0.0568422	0.0620218	0.3594109
Inverse variance weighted	23	0.0051118	0.0469848	0.9133643
Simple mode	23	0.0898050	0.1376458	0.5208798
Weighted mode	23	0.1241377	0.1114381	0.2773186

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.88180	21	0.0601828
Inverse variance weighted	31.90667	22	0.0790011

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008897	0.006952	0.8993788

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009673	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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