Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 945)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1546177	0.0998199	0.1363293
Weighted median	23	0.0467566	0.0565626	0.4084436
Inverse variance weighted	23	0.0444713	0.0390155	0.2543549
Simple mode	23	0.0352306	0.0995997	0.7269144
Weighted mode	23	0.0352306	0.0765880	0.6500288

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.41012	21	0.8513465
Inverse variance weighted	19.10538	22	0.6388123

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.012226	0.0056423	0.0418937

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006183	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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