Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 944)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0424567	0.0998198	0.6749210
Weighted median	23	0.0683733	0.0573955	0.2335491
Inverse variance weighted	23	0.0332866	0.0390155	0.3935685
Simple mode	23	0.0384138	0.1019268	0.7098761
Weighted mode	23	0.0690787	0.0628791	0.2838227

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.42817	21	0.4943041
Inverse variance weighted	20.43813	22	0.5556539

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005631	0.0056423	0.9214452

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006414	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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