Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 943)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0343545	0.0998202	0.7341455
Weighted median	23	-0.0930461	0.0546468	0.0886279
Inverse variance weighted	23	-0.0848661	0.0390156	0.0296166
Simple mode	23	-0.1792427	0.0910450	0.0617100
Weighted mode	23	-0.0819568	0.0657043	0.2253817

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.41217	21	0.9541469
Inverse variance weighted	11.71441	22	0.9629997

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031019	0.0056423	0.588285

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004984	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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