Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 942)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0731004	0.1222189	0.5561628
Weighted median	23	-0.0260335	0.0558814	0.6413075
Inverse variance weighted	23	-0.0017343	0.0471611	0.9706649
Simple mode	23	-0.0801357	0.0985999	0.4250777
Weighted mode	23	-0.0425667	0.0597342	0.4835825

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.48173	21	0.0660059
Inverse variance weighted	32.14512	22	0.0749553

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0045956	0.0069084	0.5131515

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009741	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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