Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 941)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0266078	0.1117589	0.8141253
Weighted median	23	0.0587653	0.0574019	0.3059522
Inverse variance weighted	23	0.0447682	0.0427090	0.2945397
Simple mode	23	0.0927533	0.1147633	0.4276206
Weighted mode	23	0.0826734	0.0849603	0.3410910

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.32398	21	0.1943643
Inverse variance weighted	26.36304	22	0.2364216

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011152	0.0063172	0.8615614

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008388	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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