Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 940)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0433782	0.1010551	0.6721109
Weighted median	23	-0.0092857	0.0569743	0.8705341
Inverse variance weighted	23	-0.0239800	0.0390155	0.5388011
Simple mode	23	-0.1368940	0.1116410	0.2330872
Weighted mode	23	-0.0051317	0.0694450	0.9417611

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.52283	21	0.4274385
Inverse variance weighted	21.56741	22	0.4859482

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011912	0.0057121	0.8368115

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000665	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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