Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 94)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1580090	0.1066982	0.1534829
Weighted median	23	0.0503160	0.0568888	0.3764468
Inverse variance weighted	23	0.0392837	0.0421389	0.3512105
Simple mode	23	0.0772403	0.1102441	0.4908782
Weighted mode	23	0.1176732	0.0667919	0.0919971

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.99388	21	0.2933553
Inverse variance weighted	25.66363	22	0.2664039

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0072909	0.0060311	0.2401423

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008084	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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