Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 939)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0627528	0.0998207	0.5363534
Weighted median	23	-0.0101491	0.0558366	0.8557683
Inverse variance weighted	23	-0.0092474	0.0390156	0.8126428
Simple mode	23	-0.0228870	0.0930408	0.8079712
Weighted mode	23	-0.0296458	0.0693354	0.6731195

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.29888	21	0.6928368
Inverse variance weighted	17.63800	22	0.7272224

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032858	0.0056424	0.5665387

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005362	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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