Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 938)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1558607	0.1294157	0.2418563
Weighted median	23	0.0678865	0.0653423	0.2988341
Inverse variance weighted	23	0.0345186	0.0506264	0.4953463
Simple mode	23	-0.0134128	0.1375791	0.9232185
Weighted mode	23	-0.0687317	0.1284431	0.5979391

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.29996	21	0.0261671
Inverse variance weighted	37.04419	22	0.0233931

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0074517	0.0073153	0.3199631

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011462	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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