Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 936)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0981152	0.1283004	0.4529404
Weighted median	23	-0.0133336	0.0601774	0.8246480
Inverse variance weighted	23	-0.0142080	0.0495799	0.7744432
Simple mode	23	-0.0498628	0.0978929	0.6155706
Weighted mode	23	-0.0339022	0.0594153	0.5740545

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.69359	21	0.0304991
Inverse variance weighted	35.52761	22	0.0340971

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0051527	0.0072521	0.4852036

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010805	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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