Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 935)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0522311	0.1111622	0.6432950
Weighted median	23	-0.0120440	0.0554416	0.8280236
Inverse variance weighted	23	-0.0576320	0.0424525	0.1746021
Simple mode	23	0.0849219	0.1061443	0.4322303
Weighted mode	23	-0.0116156	0.0786680	0.8839616

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.04382	21	0.2047831
Inverse variance weighted	26.04728	22	0.2496578

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003317	0.0062834	0.9584022

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008554	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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