Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 934)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0067035	0.0998209	0.9470932
Weighted median	23	0.0100772	0.0556463	0.8562940
Inverse variance weighted	23	-0.0177669	0.0390159	0.6488391
Simple mode	23	-0.0293427	0.0876116	0.7408593
Weighted mode	23	-0.0126674	0.0599801	0.8346801

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.05877	21	0.8199914
Inverse variance weighted	15.07327	22	0.8590745

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006794	0.0056424	0.9053023

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000463	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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