Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 933)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0979582	0.1141309	0.4004191
Weighted median	23	-0.0617194	0.0527825	0.2422762
Inverse variance weighted	23	-0.0858095	0.0435970	0.0490401
Simple mode	23	-0.1047751	0.0857183	0.2345218
Weighted mode	23	-0.0646550	0.0551661	0.2537307

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.45271	21	0.1563661
Inverse variance weighted	27.47020	22	0.1939098

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.000746	0.0064512	0.9090334

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000979	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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