Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 932)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1032101	0.1011551	0.3191903
Weighted median	23	0.0141172	0.0561895	0.8016270
Inverse variance weighted	23	0.0418229	0.0390258	0.2838674
Simple mode	23	0.1777404	0.1100488	0.1205397
Weighted mode	23	0.0075177	0.0681852	0.9132069

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.56520	21	0.4249248
Inverse variance weighted	22.01159	22	0.4591970

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0037698	0.0057178	0.5168629

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007018	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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