Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 931)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0291280	0.1144059	0.8015066
Weighted median	23	-0.0034844	0.0571533	0.9513862
Inverse variance weighted	23	0.0153653	0.0438739	0.7261779
Simple mode	23	-0.0279685	0.0952748	0.7718482
Weighted mode	23	-0.0279685	0.0628515	0.6606715

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.58556	21	0.1523013
Inverse variance weighted	27.82007	22	0.1817212

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0027323	0.0064667	0.6769412

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008477	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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