Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 930)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1125017	0.1030563	0.2873527
Weighted median	23	-0.0466137	0.0585913	0.4262799
Inverse variance weighted	23	-0.0142415	0.0403470	0.7241077
Simple mode	23	0.0845787	0.1038370	0.4240695
Weighted mode	23	-0.0745158	0.0754525	0.3340933

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.38371	21	0.3776950
Inverse variance weighted	23.52742	22	0.3724789

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0060342	0.0058253	0.3120481

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000717	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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