Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 93)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0388286	0.1134158	0.7354856
Weighted median	23	-0.0422756	0.0596303	0.4783479
Inverse variance weighted	23	-0.0480652	0.0433184	0.2671797
Simple mode	23	-0.0533944	0.0964955	0.5856138
Weighted mode	23	-0.0594554	0.0678180	0.3901274

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.10998	21	0.1672423
Inverse variance weighted	27.12009	22	0.2067008

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005672	0.0064108	0.9303346

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008678	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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