Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 929)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0086699	0.1066950	0.9360054
Weighted median	23	-0.0085026	0.0597897	0.8869159
Inverse variance weighted	23	-0.0253008	0.0407719	0.5348985
Simple mode	23	0.0744980	0.1282752	0.5673000
Weighted mode	23	-0.1475792	0.1091329	0.1900213

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.99299	21	0.2933985
Inverse variance weighted	24.02575	22	0.3458811

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0010213	0.006031	0.8671463

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007408	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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