Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 928)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1315363	0.0998200	0.2017882
Weighted median	23	0.0704401	0.0558988	0.2076201
Inverse variance weighted	23	0.0595016	0.0390153	0.1272384
Simple mode	23	0.0523822	0.0948623	0.5863834
Weighted mode	23	0.1137974	0.0624826	0.0821946

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.21705	21	0.7573345
Inverse variance weighted	16.83172	22	0.7725797

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0044237	0.0056423	0.4417871

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005805	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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