Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 927)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0987506	0.1138410	0.3955038
Weighted median	23	0.0430088	0.0556925	0.4399629
Inverse variance weighted	23	0.0038284	0.0443143	0.9311544
Simple mode	23	0.0081810	0.1005500	0.9358889
Weighted mode	23	0.0433619	0.0602788	0.4794940

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.31425	21	0.1606920
Inverse variance weighted	28.38160	22	0.1633768

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0058292	0.0064348	0.3752783

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008603	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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